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E-cigarette use and the irreparable damage caused may additionally cause a vicious cycle where patients may experience frequent exacerbations despite maintaining adherence to their inhaled treatments due to its inhibitory effects in normal lung processes

Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O

The mechanisms that implicate the declining of age-related ascorbate are complex and involve multiple cell signaling pathways such as accelerated turnover, increased usage, reduced cellular uptake, and decreased absorption/reabsorption

Therefore whether the process of ferroptosis regulation, even its intervention efficiency in clinical practice, is impervious to this heterogeneity should also be considered in future studies

& Pignatelli, M

Another major limitation is the lack of standardized protocols for carotenoid intake or supplementation