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Furthermore, the HGF antagonist peptide Hinge blocked both Dihexa-induced spinogenesis and the associated increases in mEPSC frequency, confirming that Dihexa's procognitive effects are mediated specifically through the HGF/c-Met signaling system

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Based on in silico prediction, miR-124 was identified responsible for regulating BDNF transcription which was further confirmed in vitro by using human neuronal cell lines