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The proteolytic regulation of A39 is specific to the mitochondrial m -AAA protease AFG3L2, and cannot be substituted by other mitochondrial proteases that also act around the inner mitochondrial membrane 40,41

Mol Biol Rep 41:8594

Papaioannou VE, Silver LM

Primary cultures of the isolated neonatal rat ventricular cardiomyocytes were prepared from the ventricles of neonatal Sprague Dawley rats as described previously, with some modifications (52)

Hvelmeyer, N

Dosing & Reconstitution Guide Educational guide for reconstitution and nightly dosing Standard / Gradual Approach (3 mL = ~3.33 mg/mL) Frequency: Inject once daily subcutaneously in the evening, approximately 3060 minutes before bedtime [4]