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Across human studies and reviews, adverse effects are uncommon at typical supplemental intakes, and when side effects do occur, they are usually mild and gastrointestinal in nature.12 13 44 A safety-focused review published in European Review for Medical and Pharmacological Sciences summarized available clinical and non-clinical data on myo-inositol and reported that only very high intake (around 12g per day) was consistently associated with side effects specifically mild gastrointestinal symptoms such as nausea, gas/flatulence, and diarrhea.44 The authors also noted that the severity of these effects did not increase with higher doses

(PubMed) Kiremidjian-Schumacher L, Roy M, Wishe HI, Cohen MW, Stotzky G

This work is partially supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) (R01CA057341 (C.V.D)), The Leukemia and Lymphoma Society LLS 6106-14 (C.V.D.) and the Abramson Family Cancer Research Institute

Vitamin C contributes to normal collagen formation and is an antioxidant

Metaanalysis: silymarin and its combination therapy for the treatment of chronic hepatitis B

From baseline to day 8, the combined CAL02 group saw an average reduction of 60.2% in the APACHE II score, while the placebo group had a reduction of 22.1% (15.5-28.7)