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Increased sensitivity to both glutamine deprivation and GLS inhibition suggests that UPS and highly GLS + STS subtypes depend on glutamine-derived glutamate for energetic and biosynthetic demands rather than redox homoeostasis and antioxidant production, which may be achieved through additional mechanisms

10.1016/j.freeradbiomed.2021.10.022 129 ZhaoJ.ShenJ.MaoL.YangT.LiuJ.HongbinS

Ferritin levels can be difficult to interpret if infection or inflammation is present, as levels can be high even in the presence of iron deficiency

The pH of a solution can be monitored using an acidbase indicator, a substance that undergoes a color change within a specific pH range that is characteristic of that indicator

Drug discovery and development for neglected diseases: the DNDi model

Melatonin has been widely investigated for its anti-proliferative and anti-apoptotic properties on cancer cells, revealing its oncostatic effects