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however, the biological origin of aging-associated chronic inflammation is largely unknown

In addition, high levels of ROS can initiate the inflammatory process by activating several inflammatory transcription factors such as nuclear factor kappa B (NF-B), activator protein 1 (AP-1), and signal transducer and activator of transcription 3 (STAT3), as well as cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor- (TNF-) [6]

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