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Do not self-prescribe high-dose B12 based on non-specific symptoms like fatigue without medical assessment

A recent review that examined the efficacy, safety, and perspective for the future of the once-weekly GLP-1 receptor agonists exenatide, taspoglutide, albiglutide, LY2189265 and CJC-1134-PC, and compared them to the currently available agonists, exenatide BID and liraglutide QD, concluded that the long-acting agonists are not superior compared to the currently used exenatide BID and liraglutide QD regarding weight loss (127).In a separate development, an orally administered PYY3-36 and GLP-1 combination has been formulated using a sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC) carrier (127)

Mallone R, Ferrua S, Morra M, Zocchi E, Mehta K, Notarangelo LD, et al

Allergic reactions to individual components are possible, though uncommon

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