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Topical medications are the first-line therapy and include prostaglandin analogues, -blockers, -agonists, carbonic anhydrase inhibitors, and Rho-kinase inhibitors, each with distinct mechanisms and side-effect profiles [12,13,14]

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Oocytes showing a germinal vesicle (GV) chromatin configuration were considered immature, and those showing a metaphase plate and a polar body were categorized as mature metaphase II (MII) oocytes

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Treatment with GA restored the number of Bacteroidales , Enterobacterales , and Clostridiales