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Importantly, these AGE-induced alterations align with clinical observations of elevated AGE accumulation in the skin of FA patients 25 and epidemiological evidence linking high-AGE food consumption (e.g., fast food and fried/microwaved meat) with increased FA prevalence 26,27,28

In peripheral blood, ASD patients often present with elevated white blood cell counts, increased monocyte levels, and widened platelet distribution width, indicating ongoing systemic inflammation (Matta et al., 2019

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