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The growth of hypermetabolic requirement tumors, including GBM, is strongly dependent on iron as compared to normal cells [52, 53]

doi: 10.1038/s41420-024-01843-5 72 LeeCJangMJKimBHParkJYYouDJeongIGet al

Owing to their small size, they are not easily seen on Gram stain but can be visualized using dark-field microscopy, Giemsa, or Wright stain

Based on the result of the kinase screen experiment, they demonstrated the potential of a quinoxaline urea 97 ( Figure 21 ) in the inhibition of the IKK activity, and used it to confirmed the hypothesis [189]

Table 1 shows the characterization of the final formulations before drug loading