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In vivo xenograft tumors further supported this mechanism of action, indicating that caudatin treatment of tumors led to increased levels of TNFAIP1 (Tan et al., 2016) (Table 1, Row 11)

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The species cover amino acids (Ala, Arg, Asp, Asn, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val) in Figure 4b, anions (Br , Cl , ClO , CO 3 2- , F , HCO 3 , HPO 4 2- , H 2 PO 4 , I , NO 2 , NO 3 ) in Figure 4c, and cations (Al 3+ , Ca 2+ , Co 2+ , Cr 3+ , Cu 2+ , Fe 2+ , Fe 3+ , K + , Li + , Mg 2+ , Mn 2+ , Na + , Ni 2+ , Pb 2+ , Ti 4+ , Zn 2+ ) in Figure 4d

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Second, altering the microbiome can have unintended effects beyond TMA production so changes should ideally be done under clinical supervision when possible

If, as in many cases, an antidepressant drug is already being taken along with the benzodiazepine, it is important to continue the antidepressant until after benzodiazepine withdrawal is complete