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Ipamorelin binds selectively to ghrelin receptors with minimal impact on cortisol, while sermorelin directly mimics growth hormone-releasing hormone (GHRH) to stimulate pituitary release

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(2) Ipamorelin Peptide and Growth Hormone Synthesis Studies conducted in vitro suggest that the interaction of Ipamorelin with GHS receptors may potentially affect somatotroph cells in the anterior pituitary gland by triggering a series of cellular signaling events

Selection depends on patient profile and clinical goals