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In proof-of-concept studies, NNMT inhibitors (NNMTis) have demonstrated promise as potential treatments for obesity and obesity-related metabolic comorbidities (e.g., T2D, fatty liver) 8,9,13

Serotonin reuptake inhibition: Enhances satiety signals Reduces appetite Improves mood (reduces emotional eating) Stabilizes cravings Similar to SSRIs but different profile Potency ratios: Why triple inhibition powerful: Attacks weight loss from multiple angles Metabolic + appetite + behavioral changes Synergistic effects stronger than single pathway But also multiplies side effect risks Different from GLP-1 single mechanism Compare to semaglutide mechanism and other weight loss approaches

In other cancers, CD38 is mainly expressed by cells in the tumor microenvironment

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