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In vitro activities of native and designed peptide antibiotics against drug sensitive and resistant tumor cell lines

He Z, Song C, Wang Z, Dong C, Jiang Q, Yu X et al (2025) Bioinformatics revealed biomarkers for diagnosis in kidney stones

As a potent selective NNMT inhibitor precisely targeting the substrate binding site (IC50 for human NNMT = 1.2 M), 5-amino-1mq liquid specifically blocks this catalytic reaction, leading to marked intracellular nicotinamide accumulation and distinctly elevated NAD+ levels via the conserved NAD+ salvage pathway

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Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a novel and effective solution, having initially been approved and marketed for glycemic control in type 2 diabetes

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex