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All yeast strains used in this study ( Supplementary Table 7 ) were grown as previously described in Hartwells Complete (HC) medium containing 2% (w/v) glucose as carbon source [70] and lacking histidine for plasmid selection unless stated otherwise

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It has also been shown that P-selenoprotein protects lipoproteins against oxidation by removing the peroxynitrite molecule that is formed due to oxidative stress within cells as a result of the reaction between superoxide ions with nitric oxide molecules at sites of inflammation [17,18,19]

The analysis uses the intent-to-treat method where all participants are analyzed as part of their randomization group, regardless of whether and when they withdrew from the study and regardless of whether or how well they complied with the study protocol

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