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It has not been fully proven that food dyes cause ASD

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Different patterns of plasma medium and long chain acylcarnitine alterations usually occurred with other biomarkers of mitochondrial energy metabolism (Figure 5, groups 2, 5, and 7)

Whether or not (and how) glutamine-glutamate metabolism of the different isoforms dictates the fate of the metabolites further down the TCA cycle needs further investigation, as well as the potential preferential role of GAC in glutamine dependency over KGA

35 Levoketoconazole (Recorlev) is another recently approved medication for CS as of December 2021

However, due to limitations in methodology and potential bias, the certainty of the evidence is low