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FGF21, by binding to its receptor FGFR1, activates the downstream PI3K/AKT signaling pathway, inhibits the activation of the inositol-requiring enzyme 1 (IRE1)/JNK pathway, and reduces the expression of apoptosis-related proteins such as C/EBP-homologous protein (CHOP) and claved-caspase3, thereby suppressing oxidative stress and apoptosis

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* * * This publication was made possible by grant number 5 U01 ES02617-15 from the National Institute of Environmental Health Sciences, National Institutes of Health, USA, and by financial support from the European Commission

Later studies indicated that specific microRNAs, such as microRNA-302, could induce reprogramming in cancer cells, thus, identifying these as candidate moieties for treatment of refractory cancer cells from a nucleotide medicine perspective (2123)

Half an hour before the end of the incubation with the indicated stimulus, Hoechst was added to each well of 24-well plates at a final concentration of 1 M

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