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Moreover, it has also been shown that TdNs can interfere in the ischemic cascade that involves excitotoxicity, apoptosis, and oxidative stress, and confer neuroprotection to the neuronal SH-SY5Y cells

10.7554/eLife.56580 ELife 68 JiangL.KonN.LiT.WangS

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This was shown in a 2017 study that also noted serum ECP correlates with disease activity indices (61)

458 While five cases of grade 3 toxicity were observed (including anorexia, increased serum aspartate aminotransferase, increased serum alkaline phosphatase, fever, and fatigue), no dose-limiting toxicities were reported