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IGF-1 signaling is widely studied because it plays a role in protein synthesis and tissue repair processes

Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms

But the countervailing data matter just as much

Arapaki A, Christopoulos P, Kalampokas E, Triantafyllidou O, Matsas A, Vlahos NF

In native physiology, the six IGFBPs perform several overlapping regulatory jobs: they extend the circulating half-life of IGF-1, they create a reservoir of hormone that can be released as needed, they modulate the amount of free peptide available to receptors, and in some contexts they exert IGF-independent effects of their own

Existing in vivo models of OSF are mainly mice or rats induced by arecoline or bleomycin