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Int J Mol Sci 26(6):2691

A., Holgado-Madruga, M., Wong, A

Trial candidates are generally adults with type 2 diabetes and a BMI over 30 who have not achieved adequate glucose or weight control with standard therapies like metformin or a single GLP-1 agonist

While compelling, these findings have not been independently replicated in peer-reviewed publications by other research groups

In naturally aged mice, FOXO4-DRI improved the testicular microenvironment and alleviated age-related testosterone secretion insufficiency with decreased p53, p21, and p16 protein levels in treated testes compared to aged controls