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Med Hypotheses 85(4):399404

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sUA and MSU crystals regulate monocyte MSU crystals induce monocyte-associated inflammation.MSU crystals directly instigate the assembly of NLRP3 inflammasome in monocytes, leading to an increase in IL-1 production ( via nuclear factor kappa-B(NF-B)/NLRP3/gasdermin D(GSDMD) signaling pathway activation

The safety profile of semaglutide 2.4 mg in STEP 5 was consistent with that in other STEP program trials 6,7,9,16,23 , and with the GLP-1 receptor agonist class in general 28

#Pharmacovigilance #DrugSafety #PVQuality #PatientSafety #Compliance #LifeSciences To view or add a comment, sign in Day 7 | Pharmacovigilance Learning Journey Today I learned about Reporting Timelines in Pharmacovigilance

Methods: A longitudinal virtual self-care program was developed by a multidisciplinary team of hepatologists, specialty nurses, data scientists and developers from Mayo Clinic Rochester and Arizona, and the Center for Digital Health Care Anyplace team