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277 Direct inhibitors of the IKK/NF-B pathway may confer clinical benefits for degenerative changes associated with both progeroid syndrome and normal aging

These include upregulating the Bax/Bcl-2 ratio in the mitochondria, 357 inducing HIF-1 degradation, 358 and involving with NF-B pathway 359 (Fig

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PMID: 3120067

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