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Radiotherapy plays a pivotal role in controlling and eradicating tumors as an adjuvant cancer treatment, either alone or in combination with other modalities (surgery, chemotherapy, immunotherapy and targeted therapy) (143)

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It was proven that the expression of ACSL4 would be suppressed in the early stage of IS, and this inhibition was induced by HIF-1

Damage of this type affects aconitase and isopropylmalate isomerase, for example, and thereby impairs the TCA cycle and the synthesis of branched-chain amino acids (Jang and Imlay, 2007)