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This strategy achieved a 41-fold increase in brain accumulation of 3D6-Fab, representing a promising platform for efficient delivery of therapeutic antibodies to the CNS for the treatment of neurological diseases

Melanin isolation Black sesame and black cumin seeds were defatted in 2-step process

Second, 2-10fold charged precursors were selected by the build in quadrupole (isolation window 1.6)

Especially, the detailed knowledge of the nanocarrier-transporter complex internalization and following sorting processes and exocytosis would enable rational design of nanocarriers capable of efficient transcytosis across the BBB by minimizing the lysosomal degradation of the nanocarrier in the endothelial cells

10.1016/j.celrep.2016.05.035 250 SettembreC.ZoncuR.MedinaD

Bielmann A, Sambiagio N, Wehr N, Gerber-Lemaire S, Bochet CG, Curty C