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Schedule: Weeks 1-4: 2mg weekly Week 5+: 4mg weekly (maintenance) This protocol reaches maintenance by week 5 and provides clinically meaningful weight loss with the mildest side effect profile

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Expressions of cleaved Caspase-1, GSDMD-NT, IL-18, and the secretion of IL-1 are also increased in the kidneys of db/db mice (127)

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