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Glutamate is the primary excitatory amino acid in the nervous system, and is produced by activated glial cells

Tirzepatide is an FDA-approved prescription medication marketed as Mounjaro for type 2 diabetes mellitus and Zepbound for chronic weight management in adults with BMI 30 kg/m, or 27 kg/m with at least one weight-related comorbidity

It increases the expression of VEGF and its receptor VEGFR2, delivering nutrients and oxygen to injured tissues to speed up healing

Tumor cells require elevated GSH levels to combat reactive oxygen species (ROS) and detoxify carcinogens

10.3390/antiox11101957 57 SekiguchiF.MiyamotoY.KanaokaD.IdeH.YoshidaS.OhkuboT.et al (2014)

316 ATF6 inhibitors Inhibition of ATF6 signaling offers another strategy to overcome chemoresistance