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Nevertheless, its favorable safety profile, natural abundance, and multi-target mechanisms make viniferin a promising candidate for adjunct therapy in type 2 diabetes mellitus (T2DM) management (Duta-Bratu 2023)

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Translational success will require (i) rigorous preclinical-to-clinical pipelines that include long-term toxicity and biodistribution studies, (ii) GMP- compliant manufacturing to ensure reproducibility and scalability, (iii) adaptive trial designs capable of evaluating patient-specific nanotherapies, and (iv) clearer regulatory alignment across FDA/EMA to classify and approve multifunctional nanoplatforms

Because NAD+ levels naturally decline with age, approaches aimed at maintaining or restoring NAD+ have become a major focus in aging research