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The current treatment protocols, characterized by the administration of substantial doses as a strategy to guarantee the delivery of adequate quantities to the intended microbial targets, exhibit drawbacks such as inadequate efficacy and the potential for adverse reactions, culminating in the evolution of drug resistance amongst the targeted microorganisms

J Control Release

CF has also been widely used to treat DM in clinical work

AA-derived eicosanoids, including prostaglandins and leukotrienes, generally promote inflammatory signaling, leukocyte recruitment, and cytokine production (59)

These procedures are planned once in 15 to 20 days to give a significant improvement in 3 to 4 treatment sessions, though maintenance is required