l propionyl carnitine Propionyl-L-carnitine hydrochloride | CAS 119793-66-7 Glycine Propionyl L-Carnitine & ED

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Romijn, J

Manuela et al

Material: Plastic

1 Introduction Numerous studies have explored the psychological wellbeing of patients with chronic diseases, revealing a high prevalence of comorbid depression and anxiety ( Several mechanisms have been proposed to underlie depression and anxiety, including alterations in monoaminergic and glutamatergic neurotransmission, deficits in neuroplasticity, hypothalamic-pituitary-adrenal (HPA) axis dysregulation, and elevated levels of neuroinflammation and oxidative stress ( Fortunately, recent studies have shown that many active compounds found in natural drugs have promising therapeutic effects on depression and anxiety and are considered highly safe ( A critical question remains: Can curcumin alleviate depression or anxiety symptoms arising from chronic diseases (DACD)

Finally, we highlight major limitations in the current evidencesuch as heterogeneous dosing regimens, the scarcity of long-term clinical data, and insufficient mechanistic validation under MASLD conditionsand propose directions for future translational research