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in Biology of Life (ed

Control mice received an equivalent volume of saline solution

The activated AKT will further activate the downstream regulatory pathway (the downstream target is mTOR), and the conversion process can be reversed by PTEN (a negative regulatory factor of PI3K) through dephosphorylation of PIP3 (229)

Trends Pharmacol Sci 10: 281285

Thus, genetic studies of histologically characterized liver biopsies, the gold standard for determining steatosis, steatohepatitis and fibrosis will aid the discovery of genetic predisposition towards disease progression