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In a phase I study of sorafenib in combination with S-1 and cisplatin for the treatment of advanced GC, pharmacokinetic analysis showed no significant difference in the sorafenib exposure between the sorafenib group and combination group, with adverse reactions including anorexia, rash, neutropenia, thrombocytopenia, and nausea (115)

How the condition is evaluated and managed Clinicians typically confirm B12 status with blood work serum B12, and often methylmalonic acid (MMA) and homocysteine, which rise when B12 is functionally low

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[PubMed] [Google Scholar] Ilic S, Drmic D, Zarkovic K, et al

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