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For example, in the strategy of targeting immune organ rejuvenation, a phase II clinical trial demonstrated the potential of miR-205 mimics to restore thymopoiesis in settings of diminished or impaired T cell output

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Mol Biotechnol 65(2):206226 Houghton CA, Fassett RG, Coombes JS (2016) Sulforaphane and other nutrigenomic Nrf2 activators: can the clinicians expectation be matched by the reality

by inhibiting effector T cell function and other antitumor immune mechanisms, Tregs facilitate immune evasion and tumor progression (19, 20)