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Their trials though appeared promising but could not be extrapolated for humans, showing the urgency for novel models to test nanobased ALS therapies (Figure 3)

doi: 10.1016/j.phyplu.2024.100540 [DOI] [Google Scholar] 163

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Prinsloo S, Rosenthal DI , Lyle R, Garcia SM, Gabel-Zepeda S, Cannon R, Bruera E, Cohen L

Thats a mechanistically different target than NSAIDs (nonsteroidal anti-inflammatory drugs), or corticosteroids, which partly explains why the compound has attracted interest in cases where conventional anti-inflammatory approaches have failed or created downstream problems

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates