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To date, several key ferroptosis-related targetssuch as GPX4, ACSL4, FTH1, and SLC7A11and upstream regulatory pathways including Nrf2, TLR4, and STING, have been identified

[9] In 2025, the United States Food and Drug Administration approved leucovorin calcium tablets for cerebral folate deficiency, bypassing standard review and drawing expert criticism

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