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Vitamin B12 is the most chemically complex of all the vitamins, and cyanocobalamin and hydroxycobalamin are synthetically derived therapeutic forms of vitamin B12.6 Hydroxycobalamin protein binding capacity is greater than that of cyanocobalamin and both of them may cause allergic reactions.6 Vitamin B12 may lead to allergic reactions because of its cobalt molecule, molecular complexity or high molecular mass

Littlejohn G, Guymer E

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There are several literature regarding use of vitamin B12 to facilitate nerve regeneration (Table 2)

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It was concluded that rabbits given the combination of AOD 9604 with hyaluronic acid apparently exhibited the least degeneration