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3 The implications of dietary patterns in cancer Malignant cells do have an innate tendency of remodelling their metabolism to fulfil the requirements of energy and metabolic intermediates necessary for unchecked cell proliferation activities [24, 113,114,115,116]

Berberine has been shown to inhibit cancer cell proliferation by upregulating LDL receptors and inhibiting lipid synthesis pathways, such as fatty acid synthase, through activation of the AMPK pathway, which reduces cholesterol and lipid accumulation in tumor cells (82)

Baklund IH, Dammen T, Moum T, Kristiansen W, Duarte DS, Castro-Marrero J, et al

This oxidative burden damages lipids, proteins, and DNA within neural and immune cells, weakening cellular resilience and fueling chronic inflammation (Rubino, 2015

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The operational process can be divided into four distinct stages, as shown in Figure 4H: (i) Under external pressure, the PDPU undergoes compressive deformation, enhancing contact between pore surfaces and facilitating charge transfer from the gas to the negatively charged PDPU, forming an electric double layer with a negatively charged surface and positively charged gas