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Astaxanthin can supplement these effects by protecting the proteins of the extracellular matrix, particularly collagen and elastin fibers, against alterations caused by oxidative stress

doi:10.1111/j.1479-828X.2010.01246.x 934. Shaarawy M, Al-Sokkary F, Sheba M, Wahba O, Kandil HO, Abdel-Mohsen I

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For example, HIF1 transcriptionally activates the mitochondrial protein NDUFA4L2 (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex 4-like 2), which decreases O 2 consumption by inhibiting electron transport chain Complex I activity