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As a pro-inflammatory cytokine, the expression of TGF-b undergoes down-regulation in rat exposed to curcumin (200 mg/kg), leading to amelioration of inflammation (Wang et al., 2019a)

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The limited human data available has not shown significant safety concerns, but long-term human safety data is still being established

TNFSF14 inhibits melanogenesis via NF-kB signaling in melanocytes

In these settings, the formulation is often administered as an IV therapy infusion or a guided subcutaneous protocol (often structured as a 6- or 12-week regimen, injecting five days a week)