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Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2

Early trial results show that these cells successfully produce insulin and respond to blood sugar levels, essentially reversing the disease

Harrison SA, Wong V, Okanoue T, Bzowej N, Vuppalanchi R, Younes Z, Younossi Z (2020a) Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: results from the STELLAR Phase 3 Trials