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M1 formed glucuronides (M12 and M13) and sulfates (M14 and M15)

Inhibition of CD70-CD27 signaling causes lipid efflux and promotes their elimination, reversing the phenomenon and enhancing antitumor immunity ( 4.1.10 Kidney cancer Kidney cancer is the 14th most commonly diagnosed cancer in the world and the 16th leading cause of cancer death worldwide ( 4.2 Immune cells Tissue-resident immune cells and tumor-associated immune cells exhibit significant differences in cholesterol metabolism due to their distinct microenvironments ( Cholesterol, as a key component of cell surface lipid rafts, plays a crucial role in immune signaling

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Cell culture experiments were contributed by GP, YO, and AA