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Since mitochondria are one of the crucial organelles involved in the manifestation of radiation-induced apoptosis, Stoyanovsky and coworkers anticipated that mitochondrial targeting of ebselen may further improve its radioprotective activity by detoxifying the mitochondrial overproduction of hydroperoxide (H 2 O 2 ) and the accumulation of lipid hydroperoxides

It produces the most consistent results, allows precise dose titration, and matches the route used in nearly all preclinical research

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doi: 10.1016/j.vetpar.2021.109526

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The percentages of viable, apoptotic, and dead cells, as well as those with active mitochondria, and the MFIs (AUs) of ROS and GSH are shown in Tables 1 and 2