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It is commonly used in in-vitro experiments investigating metabolic regulation and enzymatic signaling pathways

However, when they become circulating tumor cells, the metabolic phenotype switches to PPP, and produces sufficient NADPH and GSH to counteract ROS [192]

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The pathogenesis of PD is complex and not yet fully understood, but known mechanisms include neuroinflammation, oxidative stress, and mitochondrial dysfunction (Morris et al., 2024)