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After exposure to immunostimulants, there is an enhancement of cytokines in the fetal brain and maternal serum, amniotic fluid and placenta (Urakubo et al., 2001)

Current perspectives suggest a bidirectional interaction between peripheral immune activation and central inflammation: peripheral inflammation can enhance intracerebral inflammation via the BBB or vagal nerve pathways, while central inflammation can, in turn, stimulate the peripheral immune system (Shin et al., 2022

Overexpression of MMPs can result to excessive ECM breakdown, contributing to the pathogenesis of various respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, acute respiratory distress syndrome (ARDS) and pulmonary fibrosis [37,38,39,40]

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For those comfortable with injections (or who havent had success with pills), this trade-off can be worthwhile

Secondary clustering of fibroblasts further identified four subpopulations 17 (Supplementary Fig