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High metabolite cultivation To assess the effects of elevated extracellular metabolites, complete DMEM (5% FBS) was supplemented with 20 mM of each indicated metabolite as following: glutamine, glutamate plus NHCl (equimolar), L-aspartate plus L-citrulline (equimolar), L-arginine

Importantly, senescent cells while dead in terms of clonogenicity continue to be viable and metabolically active, over time developing a specific expression pattern of immunomodulatory factors

This would exclude the possible nonspecific contribution of the additional volume (as it may be the infusion into the anterior chamber to increase intraocular pressure above systolic pressure to induce ischemia ( Finally, the obtained findings should be summarized with the previous eye evidence

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196 showed that cystine levels are lower in tumour interstitial fluid in murine pancreatic adenocarcinomas (PDACs) than in plasma, which may indicate that cancer cells actively uptake cysteine

Acetic acid water reconstituted solutions must be used within 3 to 7 days under the same storage conditions