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doi:10.1186/1471-2105-7-386

it's a deliberate decision that impacts a compound's behavior

But there is a whole other group that is non-excreters

It is used to induce localized numbness in patients before medical procedures

Discussion The vulnerability of dopaminergic neurons to minor perturbations in redox equilibrium is enhanced by the oxidative by-products of dopamine metabolism, resulting in their selective loss in Parkinsons disease