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This synergistic approach is especially relevant for adults 40+ navigating age-related fatigue, metabolic slowdown, or increased cellular stress

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This response is often coupled with the selective activation of ATF-4 translation, which mediates a protective response including the upregulation of expression of amino acid transporters and de novo synthesis pathways 35,49

Also, in mitochondria from the brain cortex, NO production and NOS expression were decreased [68], and synaptic mitochondrial function was significantly affected [68]

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Fretham S.J.B., Carlson E.S., Georgieff M.K

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