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TGF, Transforming growth factor-beta

These channels promote intercellular communication by permitting the release of gliotransmitters such as adenosine triphosphate (ATP) and glutamate, as well as calcium ions (Ca 2+ ), which are essential in neuroinflammatory mechanisms [11]

However, under this condition, placental growth hormone may take this role as the prime regulator of maternal serum IGF-I during pregnancy [189], being of particular interest the positive expression of IGF-IR in placenta [190] and the lower expression of placental-derived IGF-I during IUGR [191]

Furthermore, structureactivity relationship (SAR) investigations of ESC derivatives have demonstrated that rational structural modifications enhance therapeutic efficacy and bioavailability, parameters essential for translating discoveries into clinical applications (Garg et al

doi: 10.1016/j.intimp.2015.08.006 96 LibbyP

It is essential first to rule out the underlying cause of depression