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Pathway enrichment analysis was performed using Reactome (Fabregat et al, 2018)

Monitoring Strategy Baseline (before starting): Complete pain assessment with validated tools Neurological examination Basic metabolic panel, HbA1c (if diabetic), vitamin B12, TSH INR if on warfarin Cardiovascular risk assessment Ongoing: Pain assessment every 4-8 weeks initially, then every 12 weeks INR weekly 2 weeks then monthly if on warfarin Neurological examination every 6-12 months Annual laboratory monitoring for long-term use 4

Testicular exposure to ionizing radiation and sperm epigenetic alterations as possible mechanisms of hereditary effects: perspectives from the viewpoint of radiation protection

Fastening of a needle: Luer-Slip (Luer-Slip)

Cerebral venous system and anatomical predisposition to high-altitude headache

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