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As expected, stimulation of hippocampal neurons transfected with mRFP--actin with HGF, Dihexa and Nle1-AngIV had significantly enhanced dendritic arbors while those additionally transfected with she-Met RNA were no different from control treated neurons (FIG

However, the protective effect of internalization is limited, since treatments of 7 days or longer will all eventually induce analgesic tolerance [37, 78, 81, 82] independent of the degree of internalization triggered by the agonist

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Puerarin-loaded PLGA were orally administered to Sprague-Dawley rats, where pharmacokinetic analysis showed a 10.52-fold increase in plasma bioavailability and a 6.46-fold increase in brain puerarin accumulation compared to oral administration of free puerarin

Direct human dose-finding trials are limited