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While freezing did not impact the concentrations of NAD + , NADH, GSH, or GSSG, it triggered the conversion of NADPH to NADP+, with about 508% of NADP + originating from oxidized NADPH (Supplementary Figure 1m-r)

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Primary PK endpoints were area under the serum concentration-time curve (AUC 0-t ) and maximum serum concentration (C max )